Polymerizable phosphoramidites with an acid-cleavable linker for eco-friendly synthetic oligodeoxynucleotide purification-Reference-Cited by-同舟云学术

Polymerizable phosphoramidites with an acid-cleavable linker for eco-friendly synthetic oligodeoxynucleotide purification

Published:2016 Issue:4 Volume:18 Page:1125-1136
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Pokharel Durga¹²³⁴,Fang Shiyue¹²³⁴

Affiliation:

1. Department of Chemistry

2. Michigan Technological University

3. Houghton

4. USA

Abstract

Purification at the hundred milligram scale is as convenient as at the sub-milligram scale. Long sequences are easily isolated from complex mixtures. The waste to product ratio is reduced by hundreds of times over known methods.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/GC/C5GC01762A

Reference26 articles.

1. Recent developments in oligonucleotide conjugation

2. The Chemistry and Biology of Oligonucleotide Conjugates

3. Oligonucleotide-based strategies to combat polyglutamine diseases

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5. Antisense oligonucleotides in cancer

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