Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo

Author:

Singh Nishant1234,Romero Manuel56273,Travanut Alessandra1234,Monteiro Patricia F.1234ORCID,Jordana-Lluch Elena62734ORCID,Hardie Kim R.62734ORCID,Williams Paul62734ORCID,Alexander Morgan R.1234ORCID,Alexander Cameron1234ORCID

Affiliation:

1. School of Pharmacy

2. University of Nottingham

3. University Park

4. UK

5. National Biofilms Innovation Centre (NBIC)

6. School of Life Sciences

7. Centre for Biomolecular Sciences

Abstract

Nanoparticles combining Quorum Sensing Inhibitors and anti-bacterials can eradicate biofilm growth in vitro and ex vivo.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Royal Society

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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