One-step facile transformation from rofecoxib to reversible mechanofluorochromic materials with dual-state emission

Author:

Chen Zhong1,Wang Zexin12,Liu Wei1ORCID,Wei Yongbo12,Ye Yuqiu1,Ke Yanbing1,Wu Tong1,Chen Nannan1,Zhou Jingming1,Zhang Xiaopo3,Tan Yingfeng4ORCID,Jiang Hong1,Zhai Xin2ORCID,Xie Lijun1ORCID

Affiliation:

1. Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou, Fujian 350007, P. R. China

2. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China

3. Key Laboratory of Tropical Translational Medicine of the Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, P. R. China

4. Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, P. R. China

Abstract

We have developed a couple of rofecoxib analogues (NOR1 and NOR2) via a one-step reaction, and both of them exhibited DSE properties.

Funder

Liaoning Revitalization Talents Program

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Key Research and Development Program of Liaoning Province

Key Research and Development Project of Hainan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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