Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells

Author:

Icsel Ceyda12345,Yilmaz Veysel T.12345ORCID,Aygun Muhittin67895,Cevatemre Buse102345,Alper Pinar111213145,Ulukaya Engin111213145

Affiliation:

1. Department of Chemistry

2. Faculty of Arts and Sciences

3. Uludag University

4. 16059 Bursa

5. Turkey

6. Department of Physics

7. Faculty of Sciences

8. Dokuz Eylul University

9. 35210 Izmir

10. Department of Biology

11. Department of Medical Biochemistry

12. Faculty of Medicine

13. University of Istinye

14. 34010 Istanbul

Abstract

Highly cytotoxic Pd(ii)/Pt(ii) complexes of saccharin with diphosphines cause cell arrest at the S phase and the production of excessive ROS, damaging mitochondria and DNA.

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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