Structural insights into fusion mechanisms of small extracellular vesicles with model plasma membranes-Reference-Cited by-同舟云学术

Structural insights into fusion mechanisms of small extracellular vesicles with model plasma membranes

Published:2021 Issue:10 Volume:13 Page:5224-5233
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Perissinotto Fabio¹²³⁴⁵^ORCID,Rondelli Valeria⁶⁷³^ORCID,Senigagliesi Beatrice¹²³,Brocca Paola⁶⁷³,Almásy László⁸⁹¹⁰^ORCID,Bottyán László⁸⁹¹⁰¹¹⁹^ORCID,Merkel Dániel Géza⁸⁹¹⁰¹¹⁹,Amenitsch Heinz¹²¹³¹⁴¹⁵,Sartori Barbara¹²¹³¹⁴¹⁵,Pachler Karin¹⁶¹⁷¹⁸¹⁹¹⁵,Mayr Magdalena¹⁶¹⁷¹⁸¹⁹¹⁵,Gimona Mario¹⁶¹⁷¹⁸¹⁹¹⁵,Rohde Eva²⁰²¹¹⁹¹⁵²²,Casalis Loredana¹²³^ORCID,Parisse Pietro¹²³²³²^ORCID

Affiliation:

1. Elettra Sincrotrone Trieste

2. Trieste

3. Italy

4. Center for Infection and Immunity of Lille, INSERM U1019

5. Institut Pasteur de Lille

6. Department of Medical Biotechnology and Translational Medicine

7. Università degli Studi di Milano

8. Centre for Energy Research

9. Budapest

10. Hungary

11. Wigner Research Centre for Physics

12. Institute of Inorganic Chemistry

13. Graz University of Technology

14. Graz

15. Austria

16. GMP Unit

17. Spinal Cord Injury and Tissue Regeneration Center Salzburg

18. Paracelsus Medical University (PMU)

19. Salzburg

20. Research Program “Nanovesicular Therapies”

21. Paracelsus Medical University

22. Department of Transfusion Medicine

23. CNR-IOM

Abstract

Extracellular vesicles exert their function through specific interaction with cell membrane. Through atomic force microscopy, neutron scattering and reflectometry we highlight a process deviating from simple fusion, driven by phase boundaries.

Funder

European Regional Development Fund

Università degli Studi di Milano

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR09075A

Reference69 articles.

1. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

2. Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers