A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading-Reference-Cited by-同舟云学术

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading

Published:2023 Issue:15 Volume:23 Page:3405-3423
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Scheinpflug Julia¹²^ORCID,Höfer Chris Tina¹^ORCID,Schmerbeck Sarah S.¹^ORCID,Steinfath Matthias¹,Doka Jennifer¹^ORCID,Tesfahunegn Yonatan Afework³^ORCID,Violet Norman¹,Renko Kostja¹^ORCID,Gulich Konrad¹^ORCID,John Thilo⁴,Schneider Marlon R.¹^ORCID,Wistorf Elisa¹^ORCID,Schönfelder Gilbert¹⁵,Schulze Frank¹

Affiliation:

1. German Federal Institute for Risk Assessment, German Centre for the Protection of Laboratory Animals (Bf3R), 10589 Berlin, Germany

2. Technische Universität Berlin, 13355 Berlin, Germany

3. Reykjavik University, 101 Reykjavik, Iceland

4. DRK Kliniken Westend, 14050 Berlin, Germany

5. Institute of Clinical Pharmacology and Toxicology, Charité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany

Abstract

We present a microphysiological system with the unique ability to combine perfusion, regulation of oxygen tension, and mechanical loading to culture bone tissue constructs under physiological conditions.

Funder

European External Action Service

Bundesinstitut für Risikobewertung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00154G

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