Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane-Reference-Cited by-同舟云学术

Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane

Published:2019 Issue:2 Volume:17 Page:315-320
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Procházková Eliška¹²³⁴^ORCID,Navrátil Rafael⁵⁶⁷⁸⁴^ORCID,Janeba Zlatko¹²³⁴^ORCID,Roithová Jana⁵⁶⁷⁸⁴^ORCID,Baszczyňski Ondřej¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry

2. Czech Academy of Sciences

3. 166 10 Prague 6

4. Czech Republic

5. Department of Organic Chemistry

6. Faculty of Science

7. Charles University

8. 128 43 Prague 2

Abstract

A combination of NMR and IRPD spectroscopy confirmed the existence of predicted cyclic phosphorus intermediates involved in ProTide prodrugs activation.

Funder

Akademie Věd České Republiky

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02870B

Reference22 articles.

1. Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular Metabolite

2. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus

3. Sofosbuvir, a Significant Paradigm Change in HCV Treatment

4. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

5. Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside

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