Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide-Reference-Cited by-同舟云学术

Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide

Published:2023 Issue:41 Volume:14 Page:11447-11455
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Martins Inês C. B.¹^ORCID,Larsen Anders S.¹,Madsen Anders Ø.¹^ORCID,Frederiksen Olivia Aalling²,Correia Alexandra³,Jensen Kirsten M. Ø.²^ORCID,Jeppesen Henrik S.⁴^ORCID,Rades Thomas¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

2. Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark

3. Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5, 00790 Helsinki, Finland

4. Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, D-22607 Hamburg, Germany

Abstract

Three polyamorphs of hydrochlorothiazide with distinct physicochemical properties were discovered. MD simulations show different dihedral angle distributions in polyamorphs I and II. Polyamorphs I and III were converted into polyamorph II.

Funder

Danmarks Frie Forskningsfond

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02802J

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