Quinoxaline derivatives as potent compounds against both 3CLpro and PLpro enzymes of SARS-CoV-2 virus: an insight from experimental and theoretical approaches

Author:

Noroozi-Shad Nazanin1,Sabet-Sarvestani Hossein12ORCID,Moghimi Vahid3,Afrough Toktam1,Haghbeen Kamahldin4ORCID,Eshghi Hossein1ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

2. Department of Food Additives, Food Science and Technology Research Institute, Research Centre for Iranian Academic Centre for Education, Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran

3. Department of Biology, Faculty of Science, Hakim Sabzevari University, Sabzevar, Iran

4. Department of Plant Bioproducts, National Institute of Genetic Engineering and Biotechnology, P.O. Box 14965/161, Tehran, Iran

Abstract

Inspired by favipiravir, new quinoxaline derivatives were synthesized to study possible compounds as inhibitors of SARS-CoV-2's cysteine proteases, including 3CLpro and PLpro.

Funder

Ferdowsi University of Mashhad

National Institute for Genetic Engineering and Biotechnology

Publisher

Royal Society of Chemistry (RSC)

Reference57 articles.

1. Coronavirus disease‑2019 (Review)

2. N.Coronavirus , Technical guidance: Early investigations (2020) , 2019

3. The coronavirus is here to stay — here’s what that means

4. WHO, Pneumonia of unknown cause–China, World Health Organization, 2020

5. Coronavirus disease 2019 (COVID-19): A literature review

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