Tetrahydroisoquinoline based 5-nitro-2-furoic acid derivatives: a promising new approach for anti-tubercular agents-Reference-Cited by-同舟云学术

Tetrahydroisoquinoline based 5-nitro-2-furoic acid derivatives: a promising new approach for anti-tubercular agents

Published:2023 Issue:32 Volume:47 Page:15378-15389
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nandikolla Adinarayana¹^ORCID,Khetmalis Yogesh Mahadu¹,Sangeetha Guruvelli Padma Vijaya²,Chandu Ala³,Swati ⁴,Kumar Muthyala Murali Krishna²,Sharma Vivek⁴,Murugesan Sankaranarayanan³^ORCID,Chandra Sekhar Kondapalli Venkata Gowri¹^ORCID

Affiliation:

1. Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad – 500078, Telangana, India

2. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh – 530 003, India

3. Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India

4. Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, Telangana, India

Abstract

We designed, synthesized, & tested 26 novel tetrahydroisoquinoline carbohydrazides for their anti-TB activity. NFT-12, 19 & 20 are the most active ones with MIC 0.78 μg mL−1. These compounds exhibited synergism with INH in drug combination studies.

Funder

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01907A

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