Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade-Reference-Cited by-同舟云学术

Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade

Published:2019 Issue:25 Volume:17 Page:6284-6292
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

He Yi¹²³⁴⁵,Wu Danjun⁶⁷⁸⁹^ORCID,Li Zhenghua¹²³⁴⁵^ORCID,Robeyns Koen¹⁰¹¹¹²⁵^ORCID,Van Meervelt Luc¹³²³⁴⁵,Van der Eycken Erik V.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC)

2. Department of Chemistry

3. KU Leuven

4. Leuven

5. Belgium

6. College of Pharmaceutical Science

7. Zhejiang University of Technology

8. 310014 Hangzhou

9. China

10. Institute of Condensed Matter and Nanosciences (IMCN)

11. Université Catholique de Louvain

12. B-1348 Louvain-la-Neuve

13. Biomolecular Architecture

Abstract

A post-Ugi gold-catalysed chemo- and diastereo-selective cascade dearomative spirocyclization/1,6-addition sequence is disclosed for the facile synthesis of diverse fused polyheterocyclic scaffolds bearing indole, pyrrole, benzothiophene, furan or electron-rich arene cores.

Funder

Fonds Wetenschappelijk Onderzoek

KU Leuven

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01299K

Reference73 articles.

1. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules