Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

Author:

Huang Kun12345ORCID,Marchesi Andrea12345ORCID,Hollingsworth Kristian6785,Both Peter12345,Mattey Ashley P.12345,Pallister Edward12345,Ledru Helene29105,Charnock Simon J.11125,Galan M. Carmen29105ORCID,Turnbull W. Bruce6785ORCID,Parmeggiani Fabio12345ORCID,Flitsch Sabine L.12345ORCID

Affiliation:

1. Manchester Institute of Biotechnology (MIB)

2. School of Chemistry

3. The University of Manchester

4. Manchester

5. UK

6. School of Chemistry and Asbury Centre for Structural Molecular Biology

7. The University of Leeds

8. Leeds

9. University of Bristol

10. Bristol

11. Prozomix Ltd

12. Northumberland

Abstract

A new α1,4 galactosyltransferase has been characterised and used for the synthesis of natural and non-natural cell surface trisaccharide antigens.

Funder

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Innovate UK

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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