The intriguing chemistry and biology of soraphens
Author:
Affiliation:
1. Department of Chemical Biology
2. Helmholtz Centre for Infection Research
3. 38124 Braunschweig
4. Germany
5. Center of Biomolecular Drug Research (BMWZ)
6. Leibniz University
7. 30159 Hannover
Abstract
Soraphens, discovered from the myxobacterial strain Sorangium cellulosum, have intrigued chemists and biologists due to their diverse biological effects mediated by the potent inhibition of acetyl CoA carboxylase.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NP/C9NP00008A
Reference82 articles.
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2. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (myxobacteria). I. Soraphen A1.ALPHA.: Fermentation, isolation, biological properties.
3. H. Reichenbach and G.Höfle , Discovery of a new antifungal mechanism of action: soraphen – an almost-success story , GBF annual report , Braunschweig , 1994
4. Chemistry and Fungicidal Activity of Soraphen A1α Derivatives
5. Myxobacteria: proficient producers of novel natural products with various biological activities—past and future biotechnological aspects with the focus on the genus Sorangium
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