Molecular insight into binding affinities and blockade effects of selected flavonoid compounds on the PD-1/PD-L1 pathway-Reference-Cited by-同舟云学术

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Molecular insight into binding affinities and blockade effects of selected flavonoid compounds on the PD-1/PD-L1 pathway

Published:2024 Issue:36 Volume:14 Page:25908-25917
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Guo Yan¹^ORCID,Tong Jinchang¹,Liang Jianhuai²,Shi Kaixin¹,Song Xinyue¹,Guo Zichao¹,Liu Boping²,Xu Jianguo¹^ORCID

Affiliation:

1. College of Food Science, Shanxi Normal University, Taiyuan 030031, China

2. Key Laboratory for Bio-based Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510630, China

Abstract

This study investigated the binding mechanisms of the flavonoids apigenin (Api), kaempferol (Kmp), and quercetin (Que) to the PD-L1 dimer using a combination of molecular modeling and experimental techniques.

Funder

Natural Science Foundation of Shanxi Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03877K

Reference43 articles.

1. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

2. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway

3. In silico mapping of the dynamic interactions and structure-activity relationship of flavonoid compounds against the immune checkpoint programmed-cell death 1 pathway

4. Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review

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