Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy-Reference-Cited by-同舟云学术

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Marques Mayra A.¹²³⁴⁵^ORCID,Landim-Vieira Maicon⁶⁷⁸⁹¹⁰^ORCID,Moraes Adolfo H.¹¹¹²¹³¹⁴^ORCID,Sun Bin¹⁵¹⁶¹⁷¹⁰,Johnston Jamie R.⁶⁷⁸⁹¹⁰,Dieseldorff Jones Karissa M.⁶⁷⁸⁹¹⁰,Cino Elio A.¹⁸¹²¹³¹⁴,Parvatiyar Michelle S.¹⁹⁷⁹¹⁰,Valera Isela C.¹⁹⁷⁹¹⁰,Silva Jerson L.¹²³⁴⁵^ORCID,Galkin Vitold E.²⁰²¹²²¹⁰,Chase P. Bryant²³⁷⁹¹⁰^ORCID,Kekenes-Huskey Peter M.¹⁵¹⁶¹⁷¹⁰,de Oliveira Guilherme A. P.¹²³⁴⁵^ORCID,Pinto Jose Renato⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Institute of Medical Biochemistry Leopoldo de Meis

2. National Institute of Structural Biology and Bioimaging

3. National Center of Nuclear Magnetic Resonance Jiri Jonas

4. Federal University of Rio de Janeiro

5. Rio de Janeiro

6. Department of Biomedical Sciences

7. Florida State University

8. College of Medicine

9. Tallahassee

10. USA

11. Department of Chemistry

12. Federal University of Minas Gerais

13. Belo Horizonte

14. Brazil

15. Department of Cell and Molecular Physiology

16. Loyola University Chicago

17. Maywood

18. Department of Biochemistry and Immunology

19. Department of Nutrition, Food and Exercise Sciences

20. Department of Physiological Sciences

21. Eastern Virginia Medical School

22. Norfolk

23. Department of Biological Science

Abstract

Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca²⁺-regulation of myocardial contraction.

Funder

American Heart Association

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

National Science Foundation

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem

Publisher

Royal Society of Chemistry (RSC)

Subject