Nitriles: an attractive approach to the development of covalent inhibitors-Reference-Cited by-同舟云学术

Nitriles: an attractive approach to the development of covalent inhibitors

Published:2023 Issue:2 Volume:14 Page:201-217
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Bonatto Vinícius¹^ORCID,Lameiro Rafael F.¹,Rocho Fernanda R.¹,Lameira Jerônimo¹²^ORCID,Leitão Andrei¹^ORCID,Montanari Carlos A.¹^ORCID

Affiliation:

1. Medicinal and Biological Chemistry Group, São Carlos Institute of Chemistry, University of São Paulo, Avenue Trabalhador Sancarlense, 400, 13566-590, São Carlos/SP, Brazil

2. Institute of Biological Science, Federal University of Pará, Rua Augusto Correa S/N, Belém, PA, Brazil

Abstract

This review highlights the roles of nitriles in covalent inhibitors, their reactivity, examples of pharmaceuticals containing the cyano group and recent developments of nitrile-based inhibitors.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00204C

Reference124 articles.

1. DrugBank , https://go.drugbank.com/ , (accessed May 2022)