Synthesis and biological evaluation of bergenin derivatives as new immunosuppressants-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of bergenin derivatives as new immunosuppressants

Published:2021 Issue:11 Volume:12 Page:1968-1976
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Deng Lihua¹^ORCID,Song Chengcheng¹²,Niu Youhong¹,Li Qin¹,Wang Meng¹,Wu Yan-Fen¹,Ye Xin-Shan¹^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China

2. Engineering Research Center of Glycoconjugates, Ministry of Education, Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun 130024, China

Abstract

A series of bergenin derivatives that may serve as new immunosuppressive agents have been synthesized. Among them, compounds 7 and 13 showed the strongest inhibition on mouse splenocyte proliferation (IC50 = 3.52 and 5.39 μM, respectively).

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00210D

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