Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors

Published:2017 Issue:21 Volume:7 Page:12455-12463
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ren Jie¹²³⁴,Li Yuhang¹²³⁴⁵,Ke Hongwei⁶²³⁴,Li Yanting¹²³⁴,Yang Longhe⁷⁸⁹¹⁰⁴,Yu Helin¹²³⁴,Huang Rui¹²³⁴,Lu Canzhong⁵¹¹¹²⁴,Qiu Yan¹²³⁴

Affiliation:

1. Medical College

2. Xiamen University

3. Xiamen

4. P. R. China

5. Xiamen Institute of Rare-earth Materials

6. College of Ocean and Earth Science

7. Engineering Research Center of Marine Biological Resource Comprehensive Utilization

8. Third Institute of Oceanography

9. State Oceanic Administration

10. Xiamen 361005

11. Haixi Institutes

12. Chinese Academy of Sciences

Abstract

Preventing PEA degradation by inhibition of NAAA is a novel strategy for the treatment of inflammation and pain. We reported the discovery of oxazolidone derivative as highly potent NAAA inhibitors, including 2f, 3h, 3i and 3j.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA28734D

Reference30 articles.

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