Platinum(ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function-Reference-Cited by-同舟云学术

Platinum(ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function

Published:2018 Issue:10 Volume:9 Page:1639-1648
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Qin Qi-Pin¹²³⁴⁵^ORCID,Zou Bi-Qun¹²³⁴⁵^ORCID,Hu Fei-Long⁶⁷⁸⁹^ORCID,Huang Guo-Bao¹²³⁴⁵,Wang Shu-Long¹²³⁴⁵,Gu Yun-Qiong¹²³⁴⁵,Tan Ming-Xiong¹²³⁴⁵^ORCID

Affiliation:

1. Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology

2. School of Chemistry and Food Science

3. Yulin Normal University

4. Yulin 537000

5. PR China

6. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products

7. Guangxi University for Nationalities

8. Nanning

9. P. R. China

Abstract

BrTry-Pt is a telomerase inhibitor targeting the c-myc promoter, and triggered T-24 cell apoptosis, which also caused mitochondrial dysfunction and S phase arrest.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00247A

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1. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs