An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

Author:

Liu Xingzhi12345,Zhang Hongbo678910,Cheng Ruoyu12345,Gu Yanzheng12345,Yin Yin114512,Sun Zhiyong12345,Pan Guoqing12345,Deng Zhongbin1314151617,Yang Huilin12345,Deng Lianfu678910,Cui Wenguo678910ORCID,Santos Hélder A.1819202122ORCID,Shi Qin12345

Affiliation:

1. Department of Orthopedics

2. The First Affiliated Hospital of Soochow University

3. Orthopedic Institute

4. Soochow University

5. Suzhou

6. Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases

7. Shanghai Institute of Traumatology and Orthopaedics

8. Ruijin Hospital

9. Shanghai Jiao Tong University School of Medicine

10. Shanghai 200025

11. Animal Experimental Center

12. P. R. China

13. Department of Medicine

14. James Graham Brown Cancer Center

15. University of Louisville

16. Louisville

17. USA

18. Drug Research Program

19. Division of Pharmaceutical Chemistry and Technology

20. Faculty of Pharmacy

21. University of Helsinki

22. Helsinki FI-00014

Abstract

An immunological tissue engineering scaffold is fabricated using anti-CD40 antibody grafted in electrospun fibers for inducing cancer cell apoptosis, activating immune response and promoting healthy tissue regeneration.

Funder

National Natural Science Foundation of China

Jane ja Aatos Erkon Säätiö

H2020 European Research Council

Shanghai Municipal Education Commission

Science and Technology Commission of Shanghai Municipality

Foundation of Shanghai Municipal Commission of Health and Family Planning

Natural Science Foundation of Jiangsu Province

Academy of Finland

Sigrid Juséliuksen Säätiö

Helsingin Yliopisto

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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