A 5-fluorouracil–kaempferol drug–drug cocrystal: a ternary phase diagram, characterization and property evaluation-Reference-Cited by-同舟云学术

A 5-fluorouracil–kaempferol drug–drug cocrystal: a ternary phase diagram, characterization and property evaluation

Published:2020 Issue:46 Volume:22 Page:8127-8135
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Lv Wen-Ting¹²³⁴⁵,Liu Xiao-Xu¹²³⁴⁵,Dai Xia-Lin¹²³⁴⁵^ORCID,Long Xiang-Tian⁶⁷⁵,Chen Jia-Mei¹²³⁴⁵^ORCID

Affiliation:

1. Tianjin Key Laboratory of Drug Targeting and Bioimaging

2. School of Chemistry and Chemical Engineering

3. Tianjin University of Technology

4. Tianjin 300384

5. China

6. Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

7. Tianjin 300409

Abstract

A drug–drug cocrystal of 5-fluorouracil and kaempferol was comprehensively investigated and exhibits optimized solubility behavior in comparison with individual APIs.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CE/D0CE01289K

Reference40 articles.

1. The role of co-crystals in pharmaceutical design

2. Polymorphs, Salts, and Cocrystals: What’s in a Name?

3. Cocrystals of Baicalein with Higher Solubility and Enhanced Bioavailability

4. Cocrystals of a 1,2,4-thiadiazole-based potent neuroprotector with gallic acid: solubility, thermodynamic stability relationships and formation pathways

5. Physical stability enhancement of theophylline via cocrystallization

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