Enzymatic cascade of DERA and ADH for lactone synthesis

Author:

Abdelraheem Eman1,Kuijpers Robin1,Hagedoorn Peter-Leon1ORCID,Hollmann Frank1ORCID,Hanefeld Ulf1ORCID

Affiliation:

1. Biocatalysis, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands

Abstract

This study presents a three-step one pot enzymatic cascade for the synthesis of a δ-lactone. This combination of enzymes can also be applied for the synthesis of the statin side chain.

Publisher

Royal Society of Chemistry (RSC)

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