Neurotransmitter selection by monoamine oxidase isoforms, dissected in terms of functional groups by mixed double mutant cycles-Reference-Cited by-同舟云学术

Neurotransmitter selection by monoamine oxidase isoforms, dissected in terms of functional groups by mixed double mutant cycles

Published:2019 Issue:39 Volume:17 Page:8871-8877
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hudspith L.¹²³⁴^ORCID,Shmam F.¹²³⁴^ORCID,Dalton C. F.¹²³⁴^ORCID,Princivalle A.¹²³⁴^ORCID,Turega S. M.¹²³⁴^ORCID

Affiliation:

1. Biomolecular Sciences Research Centre

2. Sheffield Hallam University

3. Sheffield

4. UK

Abstract

Double mutant cycles were constructed using neurotransmitters and synthetic substrates that measure their selective binding to one monoamine oxidase (MAO) enzyme isoform over another as a function of structural change.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01558B

Reference29 articles.

1. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

2. Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders

3. VMAT2 inhibitors for the treatment of tardive dyskinesia

4. Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders

5. Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

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