Lipodisks integrated with weak affinity chromatography enable fragment screening of integral membrane proteins

Author:

Duong-Thi Minh-Dao1234,Bergström Maria1234,Edwards Katarina5674,Eriksson Jonny5674,Ohlson Sten891011,To Yiu Ying Janet891011,Torres Jaume891011,Agmo Hernández Víctor5674

Affiliation:

1. Linnaeus University

2. Department of Chemistry and Biomedical Sciences

3. SE-39182 Kalmar

4. Sweden

5. Uppsala University

6. Department of Chemistry-BMC

7. SE-75123 Uppsala

8. Nanyang Technological University

9. School of Biological Sciences

10. Singapore 637551

11. Republic of Singapore

Abstract

Membrane proteins constitute the largest class of drug targets but they present many challenges in drug discovery.

Funder

Vetenskapsrådet

Ministry of Education - Singapore

National Research Foundation-Prime Minister's office, Republic of Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference45 articles.

1. Progress and problems in the exploration of therapeutic targets

2. Choosing membrane mimetics for NMR structural studies of transmembrane proteins

3. M. Ornatska , Organic Self-assembled Monolayers for Reconstitution of Ion Channels on Single Crystal Silcon, Iowa State University, 2003

4. Conducting Gramicidin Channel Activity in Phospholipid Monolayers

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