Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position-Reference-Cited by-同舟云学术

Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position

Published:2014 Issue:29 Volume:12 Page:5407-5426
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hasebein Peer¹²,Frehland Bastian¹²,Lehmkuhl Kirstin¹²,Fröhlich Roland³²,Schepmann Dirk¹²,Wünsch Bernhard¹²⁴⁵⁶

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster

2. D-48149 Münster, Germany

3. Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster

4. Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM)

5. University of Münster

6. Germany

Abstract

5-Substituted tetrahydro-2-benzazepines were prepared and the relationship between the structure, in particular the stereochemistry, and the σ₁ affinity was analyzed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00510D

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