Drug resistance-free cytotoxic nanodrugs in composites for cancer therapy

Author:

Jana Batakrishna12345,Kim Dongkap67895,Choi Huyeon12345,Kim Minsoo67895,Kim Kibeom12345ORCID,Kim Sangpil12345,Jin Seongeon12345,Park Myoung-Hwan101112513ORCID,Lee Kwan Hyi67895,Yoon Cheolho1415165,Lee Byoung-Seok171819205,Kang Min-Sung2122231924,Lim Hyun-Ji252627165,Park Eun-Jung252627165,Jeong Youngdo67895ORCID,Ryu Ja-Hyoung12345ORCID,Kim Chaekyu12345

Affiliation:

1. Department of Chemistry

2. School of Natural Sciences

3. Ulsan National Institute of Science and Technology

4. Ulsan 44919

5. Republic of Korea

6. Center for Biomaterials

7. Biomedical Research Institute

8. Korea Institute of Science and Technology

9. Seoul 02792

10. Nanobiomaterials Research Institute

11. Sahmyook University

12. Seoul 01795

13. Department of Chemistry and Life Science

14. Seoul Center

15. Korea Basic Science Institute

16. Seoul

17. Life Safety Toxicity Research Division

18. Department of Advanced Toxicology Research

19. Korea Institute of Toxicology

20. Daejeon

21. General Toxicology Research Group

22. In Vivo Hazard Evaluation and Research Division

23. Jeonbuk Branch Institute

24. Jeollabuk-do

25. East-West Medical Science Research Institute

26. Kyung Hee Medical Science Research Institute

27. Kyung Hee University

Abstract

A nanodrug as a macromolecular therapeutic agent was developed for addressing drug resistance in cancer therapy. The multivalent interactions between the nanodrugs and cytosolic components reflected their cytotoxicity.

Funder

National Research Foundation of Korea

Korea Institute of Science and Technology

Ministry of Science and ICT, South Korea

Ministry of Trade, Industry and Energy

Ministry of Health and Welfare

Ministry of Food and Drug Safety

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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