Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats

Author:

Sung Shih-Ying12,Lin Yi-Wen3,Wu Chin-Chen4,Lin Chih-Yuan2,Hsu Po-Shun12,Periasamy Srinivasan5,Nagarajan Balaji6,Hsieh Dar-Jen5ORCID,Tsai Yi-Ting127,Tsai Chien-Sung1247,Lin Feng-Yen789ORCID

Affiliation:

1. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

2. Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

3. Institute of Oral Biology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan

4. Department and Graduate Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan

5. R&D Center, ACRO Biomedical Co. Ltd, Kaoshiung, Taiwan

6. Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Virginia, USA

7. Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan

8. Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan

9. Department of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan

Abstract

ScCO2-decellularized artery graft having tremendous application in vascular regenerative medicine.It with physiological-like responses, including high potential of biocompatibility and long-term patency, lower risk of aneurysm after xenotransplantation.

Funder

Ministry of Science and Technology

Tri-Service General Hospital

Medical Affairs Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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