Microsecond molecular dynamics studies of cholesterol-mediated myelin sheath degeneration in early Alzheimer's disease-Reference-Cited by-同舟云学术

Microsecond molecular dynamics studies of cholesterol-mediated myelin sheath degeneration in early Alzheimer's disease

Published:2022 Issue:1 Volume:24 Page:222-239
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Gupta Mayuri¹^ORCID,Weaver Donald F.¹²^ORCID

Affiliation:

1. Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto, M5T 0S8, Canada

2. Departments of Chemistry, Medicine and Pharmaceutical Sciences, University of Toronto, Toronto, ON, M55 3H6, Canada

Abstract

Extensive microsecond MD simulations were performed for heterogeneous reference membranes and physiologically relevant model myelin sheath membrane with systematically varied cholesterol composition to understand early Alzheimer's disease pathology.

Funder

Canada Research Chairs

Krembil Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D1CP03844C

Reference105 articles.

1. Imaging the evolution and pathophysiology of Alzheimer disease

2. Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

3. Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

4. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

5. Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease

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