Micro-flow heteroatom alkylation <i>via</i> TfOH-mediated rapid <i>in situ</i> generation of carbocations and subsequent nucleophile addition-Reference-Cited by-同舟云学术

Micro-flow heteroatom alkylation via TfOH-mediated rapid in situ generation of carbocations and subsequent nucleophile addition

Published:2024 Issue:18 Volume:60 Page:2497-2500
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Matsuura Yuma¹,Fuse Shinichiro¹^ORCID

Affiliation:

1. Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan

Abstract

A rapid micro-flow nucleophilic substitution reaction was developed using carbocations generated from diarylmethanol and trifluoromethanesulfonic acid.

Funder

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC06308A

Reference37 articles.

1. Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

2. Transformation of carbinols by dichlorotris(triphenylphosphine)ruthenium and by some other transition-metal catalysts

3. Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited

4. Borrowing Hydrogen for Organic Synthesis

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3. Correction: Micro-flow heteroatom alkylation via TfOH-mediated rapid in situ generation of carbocations and subsequent nucleophile addition;Chemical Communications;2024