Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2-Reference-Cited by-同舟云学术

Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2

Published:2023 Issue:7 Volume:14 Page:1260-1271
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gil-Moles Maria¹²^ORCID,O'Beirne Cillian¹,Esarev Igor V.¹,Lippmann Petra¹,Tacke Matthias³,Cinatl Jindrich⁴,Bojkova Denisa⁴,Ott Ingo¹^ORCID

Affiliation:

1. Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany

2. Departamento de Química, Universidad de La Rioja, Centro de Investigación de Síntesis Química (CISQ), Complejo Científico Tecnológico, 26004 Logroño, Spain

3. School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland

4. Institute of Medical Virology, Universitätsklinikum Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt, Germany

Abstract

Silver NHC complexes are potent uncompetitive inhibitors of SARS-CoV-2 PLpro with distinct antiviral efficacy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00067B

Reference66 articles.

1. Non Platinum Metal Complexes as Anti-cancer Drugs

2. Organometallic Anticancer Compounds

3. Metallodrugs in Medicinal Inorganic Chemistry

4. Metal complexes as a promising source for new antibiotics

5. What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

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