Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(<scp>iv</scp>)/naringin complex-Reference-Cited by-同舟云学术

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Published:2024 Issue:19 Volume:48 Page:8556-8568
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Restrepo Andrés G.¹^ORCID,Huamani Angel L.¹^ORCID,Velásquez Bravo Alexandra¹^ORCID,González Pablo J.²^ORCID,Naso Luciana G.¹^ORCID,Ferrer Evelina G.¹^ORCID,Williams Patricia A. M.¹^ORCID

Affiliation:

1. Centro de Química Inorgánica (CEQUINOR, UNLP, CONICET, asociado a CICPBA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv. 120 No 1465, CP 1900 La Plata, Buenos Aires, Argentina

2. Departamento de Física, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral and CONICET, S3000ZAA Santa Fe, Argentina

Abstract

Replacement of phen in [VO(Narg)2] induces greater π electronic delocalization, thus improving antioxidant action. However, due to its lipophilic character, cellular uptake of V is increased, leading to enhanced pro-oxidant and anticancer effects.

Funder

Agencia Nacional de Promoción Científica y Tecnológica

Universidad Nacional de La Plata

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D4NJ00655K

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