Clustered nanobody–drug conjugates for targeted cancer therapy-Reference-Cited by-同舟云学术

Clustered nanobody–drug conjugates for targeted cancer therapy

Published:2020 Issue:65 Volume:56 Page:9344-9347
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Tiantian¹²³⁴⁵,Liu Manman¹²³⁴⁵,Huang Hai¹²³⁴⁵^ORCID,Sheng Yaping¹²³⁴⁵,Xiao Haihua⁶⁷⁸⁹¹⁰,Liu Yangzhong¹²³⁴⁵^ORCID

Affiliation:

1. The First Affiliated Hospital of USTC

2. Division of Life Sciences and Medicine

3. Department of Chemistry

4. University of Science and Technology of China

5. Hefei

6. Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry

7. Institute of Chemistry

8. Chinese Academy of Sciences

9. Beijing 100190

10. China

Abstract

A novel clustered nanobody–drug conjugate is constructed by a site-specific ligation of a nanobody to dendrimeric-lysine, which enhances drug efficacy and reduces side-effects.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Development Foundation of Hefei Center for Physical Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC03396K

Reference31 articles.

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5. Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

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