Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)-Reference-Cited by-同舟云学术

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

Published:2016 Issue:3 Volume:7 Page:2347-2352
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Barber David M.¹²³⁴,Schönberger Matthias¹²³⁴,Burgstaller Jessica⁵⁶⁴,Levitz Joshua⁷⁸⁹¹⁰,Weaver C. David¹¹¹²¹³¹⁰,Isacoff Ehud Y.⁷⁸⁹¹⁰¹⁴,Baier Herwig⁵⁶⁴,Trauner Dirk¹²³⁴

Affiliation:

1. Department of Chemistry and Center for Integrated Protein Science

2. Ludwig Maximilians University Munich

3. 81377 Munich

4. Germany

5. Max Planck Institute of Neurobiology

6. 82152 Martinsried

7. Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute

8. University of California

9. Berkeley

10. USA

11. Department of Pharmacology and Institute of Chemical Biology

12. Vanderbilt University School of Medicine

13. Nashville

14. Physical Bioscience Division

Abstract

We describe the development of the photoswitchable agonistLOGO, which activates GIRK channels in the dark and is rapidly deactivated upon exposure to long wavelength UV irradiation.LOGOcan be used to optically silence action potential firing in dissociated hippocampal neurons and exhibits activityin vivo, controlling the motility of zebrafish larvae in a light-dependent fashion.

Funder

European Commission

European Research Council

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04084A

Reference55 articles.

1. Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles