Interaction of partially denatured insulin with a DSPC floating lipid bilayer-Reference-Cited by-同舟云学术

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Interaction of partially denatured insulin with a DSPC floating lipid bilayer

Published:2016 Issue:3 Volume:12 Page:824-829
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Dennison A. J. C.¹²³⁴⁵,Jones R. A. L.⁶⁷⁸,Staniforth R. A.⁹⁷⁸,Parnell A. J.⁶⁷⁸

Affiliation:

1. University Grenoble Alpes

2. IBS

3. F-38044 Grenoble, France

4. Institut Laue-Langevin

5. Grenoble, France

6. Department of Physics and Astronomy

7. The University of Sheffield

8. Sheffield S3 7RH, UK

9. Department of Molecular Biology and Biotechnology

Abstract

Using neutron reflectivity we measure partitioning of destabilised insulin to the membrane interior. These perforation events will adversely affect the cell membrane permeability, which is key to life.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SM/C5SM02502H

Reference31 articles.

1. Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

3. Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

4. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

5. The Effect of Alzheimer’s Aβ Aggregation State on the Permeation of Biomimetic Lipid Vesicles

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