Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand-Reference-Cited by-同舟云学术

Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand

Published:2022 Issue:53 Volume:12 Page:34176-34184
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Höing Alexander¹^ORCID,Struth Robin²^ORCID,Beuck Christine³^ORCID,Rafieiolhosseini Neda⁴^ORCID,Hoffmann Daniel⁴^ORCID,Stauber Roland H.⁵^ORCID,Bayer Peter³^ORCID,Niemeyer Jochen²^ORCID,Knauer Shirley K.¹^ORCID

Affiliation:

1. Molecular Biology II, Center of Medical Biotechnology (ZMB)/Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 5, 45141 Essen, Germany

2. Organic Chemistry, Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45141 Essen, Germany

3. Structural and Medicinal Biochemistry, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45141 Essen, Germany

4. Bioinformatics and Computational Biophysics, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45141 Essen, Germany

5. Molecular and Cellular Oncology/ENT, University Medical Center Mainz (UMM), Langenbeckstrasse 1, 55101 Mainz, Germany

Abstract

“Targeting two for the price of one” – a selective bisphosphate ligand allows dual inhibition of threonine aspartase 1 by simultaneously addressing independent key functions – its protein–protein interaction-based activation and enzymatic function.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA06019A

Reference69 articles.

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2. Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment

3. Hybrid Drugs—A Strategy for Overcoming Anticancer Drug Resistance?

4. Bivalent mTOR inhibitors — the next generation

5. A double strike at kinases

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