An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases-Reference-Cited by-同舟云学术

An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases

Published:2021 Issue:12 Volume:12 Page:2001-2015
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Lopes João Paulo B.¹,Silva Luana¹,Lüdtke Diogo S.¹^ORCID

Affiliation:

1. Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento, Gonçalves 9500, Campus do Vale, 91501-970, Porto Alegre, RS, Brazil

Abstract

Herein, we discuss the synthesis of carbohydrate derivatives exhibiting high inhibitory activity against cholinesterase enzyme and their potential therapeutic use for the treatment of Alzheimer's disease.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados

Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul

Universidade Federal do Rio Grande do Sul

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00217A

Reference107 articles.

1. Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies

2. The Cholinergic Hypothesis of Geriatric Memory Dysfunction

3. Therapeutic Potential of Multifunctional Tacrine Analogues

4. Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

5. Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer′s Disease Therapy

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