Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation-Reference-Cited by-同舟云学术

Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation

Published:2022 Issue:1 Volume:3 Page:56-68
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Pleshinger Matthew J¹,Friedrich Ryan M.²^ORCID,Hubler Zita²^ORCID,Rivera-León Adrianna M.²^ORCID,Gao Farrah²,Yan David²,Sax Joel L.²,Srinivasan Ramya²,Bederman Ilya²,Shick H. Elizabeth²,Tesar Paul J.²,Adams Drew J.²^ORCID

Affiliation:

1. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

2. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

Abstract

Inhibition of two additional cholesterol biosynthesis enzymes, SC4MOL and HSD17B7, and accumulation of their 8,9-unsaturated sterols enhance formation of oligodendrocytes. We have also identified novel inhibitors of SC4MOL and HSD17B7.

Funder

Mt. Sinai Health Care Foundation

National Institutes of Health

G. Harold and Leila Y. Mathers Foundation

Case Western Reserve University

Edward Mallinckrodt, Jr. Foundation

Case Comprehensive Cancer Center, Case Western Reserve University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

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