Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors-Reference-Cited by-同舟云学术

Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors

Published:2016 Issue:52 Volume:6 Page:46170-46185
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Vila Noemí¹²³⁴⁵,Besada Pedro¹²³⁴⁵,Viña Dolores⁶⁷⁸⁴,Sturlese Mattia⁹¹⁰¹¹¹²¹³,Moro Stefano⁹¹⁰¹¹¹²¹³^ORCID,Terán Carmen¹²³⁴⁵

Affiliation:

1. Departamento de Química Orgánica

2. Universidade de Vigo

3. Vigo

4. Spain

5. Instituto de Investigación biomédica (IBI)

6. Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)

7. Universidade de Santiago de Compostela

8. Santiago de Compostela

9. Molecular Modeling Section (MMS)

10. Dipartimento di Scienze del Farmaco

11. Università degli Studi di Padova

12. Padova

13. Italy

Abstract

A series of donepezil analogues based on phthalazin-1(2H)-one scaffold was studied as hChEIs. The biological results revealed that the structural modifications proposed significantly affected ChE inhibitory potency as well as selectivity AChE/BuChE.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA03841G

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