Brønsted acid-catalyzed C6 functionalization of 2,3-disubstituted indoles for construction of cyano-substituted all-carbon quaternary centers-Reference-Cited by-同舟云学术

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Brønsted acid-catalyzed C6 functionalization of 2,3-disubstituted indoles for construction of cyano-substituted all-carbon quaternary centers

Published:2023 Issue:17 Volume:21 Page:3691-3696
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Huang Wen-Jun¹²^ORCID,Liu Li-Xia²^ORCID,Zhou Yong-Gui²^ORCID,Wu Bo²^ORCID,Jiang Guo-Fang¹^ORCID

Affiliation:

1. Advanced Catalytic Engineer Research Center of Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P.R. China

2. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, P. R. China

Abstract

The construction of cyano-substituted all-carbon quaternary centers via Brønsted acid-catalyzed direct C6 functionalization of 2,3-disubstituted indoles with 2,2-diarylacetonitriles is reported.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00412K

Reference58 articles.

1. Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases

2. Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

3. Indole synthesis: a review and proposed classification

4. Simple indole alkaloids and those with a non-rearranged monoterpenoid unit

5. Rings in Drugs

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