Activation of the PPARγ/NF-κB pathway by A-MPDA@Fe3O4@PVP via scavenging reactive oxygen species to alleviate hepatic ischemia-reperfusion injury

Author:

Mo Dong12,Cui Wei1,Chen Linxin1,Meng Juanjuan1,Sun Yuting3,Cai Kaiyong4ORCID,Zhang Jixi4ORCID,Zhang Jianrong5,Wang Kui46,Luo Xiaohe17ORCID

Affiliation:

1. Department of Central Laboratory, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Chongqing, 40400, China

2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China

3. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China

4. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing 400044, China

5. Department of Cardiovascular Surgery, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Chongqing, 40400, China

6. Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China

7. Department of Laboratory Medicine, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Chongqing, 40400, China

Abstract

A-MPDA@Fe3O4@PVP can rapidly remove toxic ROS, regulate immune cells and activate the PPARγ/NF-κB pathway to treat hepatic ischemia-reperfusion injury.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

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