Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-l-proline type II helix conformation-Reference-Cited by-同舟云学术

Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-l-proline type II helix conformation

Published:2015 Issue:15 Volume:13 Page:4562-4569
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Aillard Boris¹²³⁴⁵,Kilburn Jeremy D.⁶⁷⁸⁹⁵,Blaydes Jeremy P.¹⁰¹¹³⁴⁵,Tizzard Graham J.¹²³⁴⁵,Findlow Stuart¹²³⁴⁵,Werner Jörn M.¹²³⁴⁵,Bloodworth Sally¹²³⁴⁵

Affiliation:

1. Chemistry

2. Faculty of Natural and Environmental Sciences

3. University of Southampton

4. Southampton

5. UK

6. School of Biological and Chemical Sciences

7. Queen Mary

8. University of London

9. London

10. Cancer Sciences

11. Faculty of Medicine

12. Centre for Biological Sciences

Abstract

Stereoselective synthesis of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane mimic of Xaa-trans-Pro in poly-l-proline type II helix conformation is reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00180C

Reference65 articles.

1. Left-handed Polyproline II Helices Commonly Occur in Globular Proteins

2. Polyproline-II Helix in Proteins: Structure and Function

3. Polyproline Helices in Protein Structures: A Statistical Survey

4. A survey of left-handed polyproline II helices

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