Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors-Reference-Cited by-同舟云学术

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

Published:2020 Issue:76 Volume:56 Page:11203-11206
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hosoya Yusuke¹²³⁴⁵,Nojo Wataru⁶⁷⁸⁹⁵,Kii Isao¹²³⁴⁵^ORCID,Suzuki Takanori⁶⁷⁸⁹⁵^ORCID,Imanishi Miki¹⁰¹¹¹²⁵^ORCID,Ohkanda Junko¹²³⁴⁵^ORCID

Affiliation:

1. Academic Assembly

2. Institute of Agriculture

3. Shinshu University

4. Nagano 399-4598

5. Japan

6. Department of Chemistry

7. Faculty of Science

8. Hokkaido University

9. Sapporo 060-0810

10. Institute for Chemical Research

11. Kyoto University

12. Kyoto 611-0011

Abstract

Fluorescent-based library screening for the DNA-binding of disordered BMAL1 and CLOCK identified heterocyclic inhibitors which possess low micromolar activity.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Astellas Foundation for Research on Metabolic Disorders

Naito Foundation

Uehara Memorial Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC04861E

Reference45 articles.

1. Understanding protein non-folding

2. Intrinsic Disorder in Cell-signaling and Cancer-associated Proteins

3. Targeting intrinsically disordered proteins at the edge of chaos

4. Intrinsically disordered proteins in cellular signalling and regulation

5. Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

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