Small RNA sequencing revealed dysregulated piRNAs in Alzheimer's disease and their probable role in pathogenesis

Author:

Roy Jyoti12345,Sarkar Arijita6785,Parida Sibun6785,Ghosh Zhumur6785,Mallick Bibekanand12345ORCID

Affiliation:

1. RNAi and Functional Genomics Laboratory

2. Department of Life Science

3. National Institute of Technology Rourkela

4. Odisha

5. India

6. Bioinformatics Centre

7. Bose Institute

8. Kolkata 700054

Abstract

For the first time, this study reports specific piRNA signatures in a healthy human brain and an AD-diagnosed brain and decrypted the regulatory roles of dysregulated piRNAs in the pathogenesis of AD.

Funder

Science and Engineering Research Board

Council for Scientific and Industrial Research

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

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