One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome

Author:

Chen Peng12345ORCID,Hei Maofang67345,Kong Lili12345,Liu Yinyin12345,Yang Yu12345,Mu Haibo12345,Zhang Xiuyun12345,Zhao Shanting67345,Duan Jinyou12345

Affiliation:

1. Shaanxi Key Laboratory of Natural Products & Chemical Biology

2. College of Chemistry & Pharmacy

3. Northwest A&F University

4. Yangling 712100

5. China

6. State Key Laboratory of Crop Stress Biology for Arid Areas

7. College of Veterinary Medicine

Abstract

By performing a pyrosequencing-based analysis of bacterial community, we detected that one Ginkgo biloba polysaccharide reversed depression-associated gut dysbiosis and increased the richness of Lactobacillus species which has been proven to be a path to relieve depression.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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