Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties-Reference-Cited by-同舟云学术

Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties

Published:2019 Issue:35 Volume:9 Page:20356-20369
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Santos Sabrina Neves¹²³⁴⁵,Alves de Souza Gabriela¹²³⁴⁵,Pereira Thiago Moreira¹²³⁴⁵,Franco Daiana Portella¹²³⁴⁵,de Nigris Del Cistia Catarina⁶³⁴⁵,Sant'Anna Carlos Mauricio R.⁶³⁴⁵,Lacerda Renata Barbosa¹²³⁴⁵,Kümmerle Arthur Eugen¹²³⁴⁵^ORCID

Affiliation:

1. Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory)

2. Chemistry Institute

3. Universidade Federal Rural do Rio de Janeiro

4. Rio de Janeiro

5. Brazil

6. Programa de Pós-Gradução em Química (PPGQ)

Abstract

Regioselective microwave synthesis of N-protected and N-deprotected 1,5-diaryl-3-amino-1,2,4-triazoles in up to 1 h. Derivatizations furnish new scaffolds for cholinesterase mixed-type inhibition.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA04105B

Reference39 articles.

1. Synthesis of 1,2,4-Oxadiazole-, 1,3,4-Oxadiazole-, and 1,2,4-Triazole-Derived Dipeptidomimetics