Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation
Author:
Affiliation:
1. Institute of Macromolecular Chemistry
2. Czech Academy of Sciences
3. 162 06 Prague 6
4. Czech Republic
5. Institut des Biomolécules Max Mousseron
6. Université Montpellier
7. ENSCM
8. Faculté de Pharmacie
9. Montpellier Cedex 5
Abstract
Amphiphilic poly(ε-caprolactone)-graft-(poly-N-(2-hydroxypropyl) methacrylamide) copolymers with tunable solution properties form stable micelles with high drug payload via simultaneous encapsulation and pH-sensitive covalent conjugation.
Funder
Grantová Agentura České Republiky
Ministerstvo Školství, Mládeže a Tělovýchovy
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2020/PY/D0PY00609B
Reference62 articles.
1. The dawning era of polymer therapeutics
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3. Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles
4. PEG-Graft Density Controls Polymeric Nanoparticle Micelle Stability
5. Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer–doxorubicin conjugates in nude mice
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