Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety-Reference-Cited by-同舟云学术

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Published:2017 Issue:40 Volume:15 Page:8655-8660
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sansook Supojjanee¹²³⁴⁵,Ocasio Cory A.¹²³⁴⁵^ORCID,Day Iain J.¹²³⁴⁵^ORCID,Tizzard Graham J.⁶⁷⁸⁹⁵^ORCID,Coles Simon J.⁶⁷⁸⁹⁵^ORCID,Fedorov Oleg¹⁰¹¹¹²¹³⁵,Bennett James M.¹⁰¹⁴¹⁵¹⁶,Elkins Jonathan M.¹⁰¹⁴¹⁵¹⁶^ORCID,Spencer John¹²³⁴⁵^ORCID

Affiliation:

1. Dept of Chemistry

2. School of Life Sciences

3. University of Sussex

4. Falmer

5. UK

6. UK National Crystallography Service

7. Chemistry

8. University of Southampton

9. Southampton

10. Structural Genomics Consortium

11. Nuffield Department of Clinical Medicine

12. University of Oxford

13. Oxford

14. Universidade Estadual de Campinas

15. Campinas

16. Brazil

Abstract

A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF₅-substituted oxindoles with a range of aldehydes.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02289A

Reference30 articles.

1. Targeting cancer with small molecule kinase inhibitors

2. Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

3. A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

4. A public-private partnership to unlock the untargeted kinome

5. A quantitative analysis of kinase inhibitor selectivity

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