Chiral cyclopropenimine-catalyzed enantioselective Michael additions between benzophenone-imine of glycine esters and α,β-unsaturated pyrazolamides-Reference-Cited by-同舟云学术

Chiral cyclopropenimine-catalyzed enantioselective Michael additions between benzophenone-imine of glycine esters and α,β-unsaturated pyrazolamides

Published:2023 Issue:40 Volume:47 Page:18811-18817
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Bai Yu-Jun¹²,Wang Xue-Ying¹,Zhu Si-Kai¹,Zheng Xiao-Hui²^ORCID,Zhang Sheng-Yong¹,Wang Ping-An¹^ORCID

Affiliation:

1. A Department of Medicinal Chemistry and Pharmaceutics Analysis, School of Pharmacy, Air Force Military Medical University, Xi’an 710032, P. R. China

2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an 710069, P. R. China

Abstract

A highly chiral cyclopropenimine-catalyzed enantioselective Michael addition between benzophenone-imine of glycine esters and β-substituted α,β-unsaturated pyrazolamides has been realized to afford Michael adducts in up to 95% yield and 99% ee.

Funder

National Natural Science Foundation of China

Fourth Military Medical University

Ministry of Education and Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ02537C

Reference38 articles.

1. On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives

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4. Thyrotropin-Releasing Hormone (TRH) Analogues That Exhibit Selectivity to TRH Receptor Subtype 2

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