A general Fe-catalysed azidation of iododifluoroketones and its utilization for the synthesis of <i>gem</i>-difluoromethylenated triazoles-Reference-Cited by-同舟云学术

A general Fe-catalysed azidation of iododifluoroketones and its utilization for the synthesis of gem-difluoromethylenated triazoles

Published:2024 Issue:7 Volume:11 Page:2054-2061
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Xia¹,Liu Shixun¹,Xu Shibo¹^ORCID,Wu Shiguang¹,Wu Jingjing¹²^ORCID,Wu Fanhong¹

Affiliation:

1. School of Chemical and Environmental Engineering and Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology, Shanghai Institute of Technology, Shanghai 201418, China

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

An iron-catalysed radical azidation of iododifluoroketones with TMSN3 was developed under mild conditions to provide a concise synthesis of α-difluoroalkylazides, which could be transformed into the useful N–CF2 triazoles via the CuAAC reaction.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO02088F

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