Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles-Reference-Cited by-同舟云学术

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Published:2024 Issue:33 Volume:12 Page:8062-8066
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Ren Yupeng¹,Zeng Ling²,Tang Yingsen²,Liao Jing²,Jiang Meng²,Cao Xinxiu¹,Fan Hui¹,Chen Jinjin²^ORCID

Affiliation:

1. Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion, School of Materials Science and Engineering, Hunan University of Science and Technology, 2 Taoyuan Street, Xiangtan 411201, P. R. China

2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Abstract

Ionizable lipids with branched tails enhance the selective mRNA delivery to spleen, particularly to antigen-presenting cells.

Funder

Natural Science Foundation of Hunan Province

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Guangzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00960F

Reference21 articles.

1. mRNA – A game changer in regenerative medicine, cell-based therapy and reprogramming strategies

2. Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

3. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

4. PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

5. Advances in COVID-19 mRNA vaccine development